# Information-Specialist Search Review Request

**Review title:** Controlled 25 mg psilocybin safety in major depressive disorder  
**Protocol:** `PSILOCYBIN_INDEPENDENT_REPLICATION_PROTOCOL_V0.2.md`  
**Strategies:** `search-strategies-v0.6.csv`

Please review the proposed MEDLINE, Embase, PsycINFO, CENTRAL, registry, and citation-search approaches before execution. Specifically assess:

- translation of psilocybin, psilocin, COMP360, MDD, and TRD concepts;
- subject-heading explosion and platform syntax;
- whether the trial filter harms recall;
- spelling, truncation, adjacency, field tags, and line combinations;
- unnecessary limits;
- reproducibility of registry and grey-literature searches;
- whether safety terms should remain absent to avoid missing trials with incomplete harms indexing.

Record each recommendation in `press-search-peer-review-form.csv`, including whether it is essential, optional, accepted, or rejected with rationale. Any accepted change receives a protocol-amendment entry before the first independent search.